The Lewy body dementias (LBDs) include dementia with Lewy Bodies (DLB) and Parkinson’s disease with dementia (PDD) and they are the second to third most common cause of degenerative dementia in older people after Alzheimer’s disease. This means in the UK that approximately 130,000 people are affected by LBD and prevalence is expected to double over the next 30 years. Levels of functional disability, impaired quality of life and annual care costs in LBD are significantly greater than those associated with Alzheimer's disease.
However despite the significant numbers affected and wide range of symptoms, our understanding of how to best diagnose and treat LBD remains poor. The multisystem nature of LBD means that single solutions will not be effective. Solving problems in LBD is likely to require combined approaches and innovations working together in synergy.
In our laboratory we use a wide range of investigative and analytic techniques ranging from the clinical to advanced neuroimaging to: 1) better understand the aetiology of LBD 2) improve the early diagnosis of LBD and 3) ultimately offer better treatment and care for people with LBD.