The ENLIST-UK study is a 3-year longitudinal observational study aiming to recruit people with a diagnosis of dementia with Lewy bodies, Parkinson’s disease dementia or Alzheimer’s disease (for comparison purposes). Over the duration of the study, participants are invited to complete 5 visits (Screening, Baseline, Year 1, Year 2, Year 3). They are asked to complete neuropsychiatric questionnaires, undergo a blood test for biomarkers, and are also offered the option of a lumbar puncture to collect cerebrospinal fluid.
The main objective is to examine if the presence of clinical core features, pro inflammatory cytokines or CSF AD markers are associated with increased rate of cognitive decline. A secondary objective is to build up a large cohort of people with dementia with Lewy bodies in the UK, collecting biological samples and longitudinal clinical and cognitive data.
This is a multicentered study within the United Kingdom.